Recently accepted COV-IRT member led comprehensive review of intracellular drivers in SARS-CoV-2 Infection
Read the first review of a 3 part COVID-19 review series led by COV-IRT members. This first review focuses on what is known to-date for the key intracellular factors involved with SARS-CoV-2 infection. Stay tuned for part 2 of this series which will focus on the extracellular drivers and part 3 focusing therapeutics/anti-virals that are being investigated in the literature.
Abstract from the paper:
COVID-19, the disease caused by SARS-CoV-2, has claimed approximately 5 million lives and 257 million cases reported globally. This virus and disease have significantly affected people worldwide, whether directly and/or indirectly, with a virulent pathogen that continues to evolve as we race to learn how to prevent, control, or cure COVID-19. The focus of this review is on the SARS-CoV-2 virus’ mechanism of infection and its proclivity at adapting and restructuring the intracellular environment to support viral replication. We highlight current knowledge and how scientific communities with expertize in viral, cellular, and clinical biology have contributed to increase our understanding of SARS-CoV-2, and how these findings may help explain the widely varied clinical observations of COVID-19 patients.